Last edited by Aragami
Monday, May 18, 2020 | History

1 edition of Somatostatin analogs in diagnostics and therapy found in the catalog.

Somatostatin analogs in diagnostics and therapy

by M. Pawlikowski

  • 249 Want to read
  • 35 Currently reading

Published by Landes Bioscience in Austin, Tex .
Written in English

    Subjects:
  • Analogs and derivatives,
  • Neuroendocrine Tumors,
  • Somatostatin Receptors,
  • Biochemistry,
  • MEDICAL,
  • Somatostatin,
  • Drug therapy,
  • Diagnosis,
  • Physiology

  • Edition Notes

    Statement[edited by] Marek Pawlikowski
    SeriesMedical intelligence unit, Medical intelligence unit (Unnumbered : 2003)
    Classifications
    LC ClassificationsQP572.S59 S6635 2007eb
    The Physical Object
    Format[electronic resource] /
    Pagination1 online resource (1 v.)
    ID Numbers
    Open LibraryOL27088401M
    ISBN 101435602412
    ISBN 109781435602410
    OCLC/WorldCa174147426

    Symptomatic improvement may occur with all ()In-, (90)Y-, or ()Lu-labeled somatostatin analogs that have been used for peptide receptor radionuclide therapy (PRRT). Title:Somatostatin and its Analogs VOLUME: 17 ISSUE: 5 Author(s):Lichun Sun and David H. Coy Affiliation:Department of Pharmacy, The Fifth People's Hospital of Shanghai, Fudan University, Shanghai, China. Keywords:Hormone, somatostatin, somatostatin analogs, somatostatin receptors, receptor-targeted. Abstract:Somatostatin (SST) is a cyclic hormone-release inhibitory peptide that has high Cited by:

      Octreotide is the progenitor of the somatostatin analogues (SSA) family, which includes radiopharmaceuticals suitable for SPECT, PET and radionuclide therapy, within an effective theragnostic model. Nowadays, PET/CT performed using DOTA peptides radiolabeled with Gallium is considered the best molecular imaging procedure in staging and restaging of neuroendocrine tumors (NETs), Author: Luigi Mansi.   Transcript: Timothy J. Hobday, MD: Somatostatin analogs are currently used for 2 different purposes in our patients. One is to control the hormones that are .

      Somatostatin receptor imaging, by In-pentetreotide scintigraphy or PET with 68Ga-labelled somatostatin analogues, frequently identifies additional lesions that are not visible on CT or Cited by: Title: Diagnostic and Therapeutic Applications of Radiolabeled Somatostatin Analogs: Current Status in an Oncology Center VOLUME: 8 ISSUE: 20 Author(s):Donald A. Podoloff Affiliation:Texas Medical Center, Nuclear Medicine, Holcombe Boulevard, Houston, Texas, USA Keywords:therapeutic applications, somatostatin receptor, first-line therapy, neoplastic tissues, Cited by: 4.


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Somatostatin analogs in diagnostics and therapy by M. Pawlikowski Download PDF EPUB FB2

Somatostatin is a peptide isolated originally from the hypothalamus and considered as an inhibitor of growth hormone secretion.

However, further studies have shown that the peptide was ubiquitously distributed and exerts a large spectrum of physiological effects, mostly of Cited by: Provides the most up-to-date coverage of somatostatin analog use in diagnostic and therapy Integrating the specialties of endocrinology, physiology, pathology, and nuclear medicine, providing the multidisciplinary approach to the topic Focuses on future applications, novel compounds, and.

The book: Provides the most up-to-date coverage of somatostatin analog use in diagnostic and therapy Integrating the specialties of endocrinology, physiology, pathology, and nuclear medicine, providing the multidisciplinary approach to the topic Focuses on future applications, novel compounds, and areas for further research.

To overcome this limitation the long-lasting modified molecules (analogs) of somatostatin were synthesized. The present book provides comprehensive data on the application of somatostatin analogs in diagnostics and treatm. Attempts have been made to use modern somatostatin analogs for the therapy of various human cancers such as prostatic, breast, pancreatic, and lung cancers, 3, 8, 33, 57, 58, 62, 64, 68–70 but relevant palliative benefits have been obtained so far only in hepatocellular carcinoma.

71 (See the sections on specific neoplasms.) Nonpeptide somatostatin analogs (peptide mimetics) have also been developed.

Somatostatin analogs, such as octreotide, bind predominantly to sst 2 and successfully control hormone hypersecretion in patients with acromegaly, islet cell tumors and carcinoids, and (temporary) control of tumor growth is often also by: Summary. The use of radiolabeled peptides for the diagnosis and therapy of cancer has increased greatly over the last few decades.

Skillfully crafted peptide systems, which have high affinity for receptors that are overexpressed in human tumors, offer the potential to improve the characterization, grading, and eventual therapy of human by: Somatostatin is a hormone produced by the hypothalamus and some other tissues such as the pancreas and the gastrointestinal tract.

It inhibits the release of growth hormone from the anterior pituitary, and insulin and glucagon from the pancreas. Somatostatin and its Analogs. Rapid diagnostics and innovative methods of management, including a wider range of treatment options, have resulted in a reduction in co-morbidities associated.

Somatostatin analogs in neuroendocrine tumors. Gastroenteropancreatic tumors are derived from pancreatic islet cells and the stomach, duodenum, and small intestine. Islet cell tumors are named according to the hormone(s) they secrete, and the symptoms are dependent on these hormone(s).Cited by: Summary.

This chapter reviews the basis of somatostatin (SST) analogue therapy and the current analogues available and under investigation. Present analogues decrease the secretion of bioactive products from tumors but have a limited anti-proliferative by: 1.

Somatostatin analogs are unproven for treating other conditions not listed above as proven due to the lack of published clinical evidence of safety and/or efficacy in published peer-reviewed medical literature.

APPLICABLE CODES The following list(s) of procedure and/or diagnosis codes is provided for reference purposes only and may not be all. Somatostatin analogs are currently used in the treatment of neuroendocrine tumors. In addition, the expression of somatostatin receptors by many tumors allows their visulaization by radionuclide-coupled somatostatin analogs.

Targeted chemo- and radiotherapy is currently being developed for these by:   Somatostatin analogues have been used to treat the symptoms of NETs for decades and also have an antineoplastic effect, markedly prolonging progression-free survival. Somatostatin analogues are likely to remain the cornerstone of treatment for most patients with advanced NETs.

Promising new combination therapies are undergoing clinical investigation. Somatostatin and somatostatin analogues: diagnostic and therapeutic uses. de Herder WW(1), Lamberts SW. Author information: (1)Division of Endocrinology, Department of Internal Medicine, University Hospital, Erasmus Medical Center Rotterdam, Rotterdam, The Netherlands.

[email protected] by:   The book: Provides the most up-to-date coverage of somatostatin analog use in diagnostic and therapy Integrating the specialties of endocrinology, physiology, pathology, and nuclear medicine, providing the multidisciplinary approach to the topic Focuses on future applications, novel compounds, and areas for further researchBrand: Wiley.

Somatostatin does a number of things. It slows down or stops the production of a number of hormones such as insulin and gut hormones. It also controls the emptying of the stomach and bowel. A somatostatin analogue is a man made (synthetic) version of somatostatin.

It slows down the production of hormones, especially the growth hormone and serotonin. Featuring chapters from specialists in endocrinology, physiology, pathology, and nuclear medicine, this book provides a multidisciplinary approach to a wide variety of issues concerning somatostatin and its analogues.

The book Provides the most up-to-date coverage of somatostatin analog use in diagnostic and therapy Integrating the specialties of. Somatostatin receptor scintigraphy with OctreoScan has been recommended as the best imaging technique in these tumors in the localization and staging procedure.

SS analogs, coupled to radioisotope or cytotoxic drugs, create another class of SS molecules, very promising in the therapy of the endocrine glands tumors and in other by: The high expression of sst2 receptors in GEP tumours has led to the successful clinical application of somatostatin analogues for both diagnosis and therapy.

Octapeptide analogues such as octreotide and lanreotide are used in hormonal disorders, gastrointestinal disorders and cancer in order to treat GH- or thyroid-stimulating hormone-secreting Cited by:.

Featuring chapters from specialists in endocrinology, physiology, pathology, and nuclear medicine, this book provides a multidisciplinary approach to a wide variety of issues concerning somatostatin and its analogues.

The book: Provides the most up-to-date coverage of somatostatin analog use in diagnostic and therapy.The long-acting analogues of somatostatin have an established place in the medical treatment of patients with neuroendocrine tumours.

They act through binding with specific, high-affinity membrane receptors. Somatostatin analogue therapy is an effective and safe treatment for most growth hormone and thyrothropin-secreting pituitary by: Somatostatin analogs have a well-established role in the management of esophageal varices and peptic ulcer disease [10, 14].

The first reported use of somatostatin analogs in angiodysplasia or occult bleeding was a small case series described in using subcutaneous by: 4.